โครงการวิจัย (Current Project)
List of research projects
2009-2011 Molecular mechanisms involved in the cross-talk between chemokine GPCR and growth factor RTK signal transduction in metastatic breast cancer epithelial cells, Thailand Research Fund (TRF) and Commission on Higher Education (CHE) (Principle investigator)
2009-2011 Anti-cancer mechanisms of vitamin C in different solid tumours, The Thammasat University Research Grant (Principle investigator)
2011-2014 Characterization and detection of cytokines in immunological diseases, The National Research University Project of Thailand, Office of Higher Education Commission (Coinvestigator)
2013-2014 Prevalence and effect of hepatitis virus infection on the severity of HIV infection and hepatotoxicity in HIV-infected Thai individuals receiving anti-retroviral therapy, The fiscal year budget 2013-2014 of Thammasat University (Principle investigator)
2014 Effect of SDF-13’A polymorphism on HIV and hepatitis virus infection in Thais, The Research Grant for Graduate Studies from the National Research Council of Thailand and from Thammasat University (Fiscal year 2014) (Research project advisor)
2015 Mechanisms of CXCR4/CXCR7/CXCL12 signaling in breast cancer cells in response to high-dose vitamin C, Faculty of Allied Health Sciences Research Grant, Thammasat University (Principle investigator)
2016 Prevalence and risk factors of chronic liver disease, and relationship of CXCL9-11 plasma levels to the severity of liver disease in Thai HIV-infected patients on anti-retroviral therapy, The Fiscal Year Budget 2016 of Thammasat University (Principle investigator)
2018 Effect of interferon gamma inducible protein 10 gene polymorphisms on liver disease in HIV-infected Thais, supported by the Research Grant for Graduate Studies from the National Research Council of Thailand (Fiscal year 2018) (Research project advisor)
2018 Prevalence of liver complications evaluated by non-invasive markers in HCV/HIV coinfected patients in Bamrasnaradura Infectious Diseases Institute, supported by the Research Grant for Graduate Studies from the National Research Council of Thailand (Fiscal year 2018) (Research project advisor)
งานวิจัยที่สนใจ (Research Interests)
Research area of interest
- Immunobiology of cancer metastasis and invasion
- Molecular virology: virus-host interaction, immunology of hepatitis and human immunodeficiency virus infection
B.Sc. (Medical Technology), Faculty of Medical Technology, Chiang Mai University, Thailand
M.Sc. (Microbiology), Department of Microbiology, Faculty of Sciences, Mahidol University, Thailand
Ph.D. (Molecular Biosciences), Discipline of Microbiology and Immunology, the School of Molecular and Biomedical Science, the University of Adelaide, South Australia, Australia
2007 Basic Immunology Course for Clinicians at Windsor Barra Hotel, Rio de janerio, Brazil, supported by Cancer Council and School of Molecular and Biomedical Science, The University of Adelaide, South Australia (August 20, 2007)
2011 Analysis of global signal transduction in cancer cells by antibody microarray, Chemokine biology laboratory, School of Molecular and Biomedical Science, The University of Adelaide, South Australia, supported by Chemokine biology laboratory, School of Molecular and Biomedical Science, The University of Adelaide, South Australia and Faculty of Allied Health Sciences, Thammasat University. (March 16-May 1, 2011)
2014 The Second Abbas’s Advanced Course in Basic and Clinical Immunology, Sayamindra building, Siriraj hospital, organized by The Allergy, Asthma and Immunology Association of Thailand (AAIAT) (November 6-8, 2014)
2016 Clinical immunology course associated with The 17th International Congress of Immunology, Melbourne convention and exhibition centre, Australia, supported by Thammasat University. (August 21, 2016)
2017 Genome Evolution of Important Infectious Diseases, at Century park hotel, Bangkok, organized by Department of Microbiology, Faculty of Sciences, Mahidol University. (December 13-15, 2017)
2017 Asian Institute in Statistical Genetics and Genomics (1st South Asian Workshop) at Thammasat University, Rangsit Campus organized by Catholic University of Korea (December 18-19, 2017)
- Thitilat Chiraunyanan, Khaimook Changri, Warisara Sretapanya, Kornanong Yuenyongchaiwat and Chareeporn Akekawatchai*. CXCL12 G801A polymorphism is associated with significant liver fibrosis in HIV–infected Thais: a cross-sectional study. Asian Pac J Allergy Immunol. 2018 Oct 15. doi: 10.12932/AP-160917-0162.
- Nalin Wongkattiya, Chareeporn Akekawatchai, Panchana Sanuansermsri, Ian Hamilton Fraser, Chayanin Pratoomsoot and Donruedee Sanguansermsri. Cheminal compositions and biological properties of essential oils from Zanthoxylum Rhetasa (Roxb.) DC and Zanthoxylum Limoella Alston. Afr J Tradit Complement Altern Med 2018 15 (2): 12-18.
- Warisara Sretapanya, Thitilat Chiraunyanan, Duangnate Pipatsatitpong, Thippawan Chuenchitra and Chareeporn Akekawatchai*. Prevalence of heptotoxicity and factors associated with transaminitis in HIV-infected Thais without hepatitis B and C coinfection. J Med Tech Assoc Thailand 2017 Dec; 45(3):6140-6156.
- Akekawatchai C*, Roytrakul S, Kittisenachai S, Isarankura-Na-Ayudhya S and Jitrapakdee S. Protein profiles associated with anoikis resistance of the metastatic MDA-MB-231 breast cancer cells. Asian Pac J Cancer Prev. 2016 March;17(2):581-90.
- Akekawatchai C*, Sretapanya W, Pipatsatitpong D and Chuenchit T. Hepatitis B and C virus coinfection and risks for the transaminitis in HIV-infected Thais on Combined anti-retroviral therapy. Asian Biomedicine 2015 June 9; 3: 353-361
- Meizhi N, Klingler-Hoffmann M, Brazzatti J, Forbes B, Akekawatchai C, Hoffmann P, McColl SR. Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line. Proteome Sci. 2013 Jan 15; 11(1): 4: 5956-11-4.
- Holland JD, Kochetkova M, Akekawatchai C, Dottore M, Lopez A and McColl SR. Differential functional activation of chemokine receptor CXCR4 is mediated by G-proteins in breast cancer cells. Cancer Res. 2006 Apr 15; 66(8):4117-24.
- Akekawatchai C, Holland JD, Kochetkova M, Wallace JC and McColl SR. Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells. J Biol Chem. 2005 Dec 2; 280(48): 39701-8.
- Ubol S, Sukwattanapan C, Maneerat Y. Inducible nitric oxide synthase inhibition delays death of rabies virus–infected mice. J Med Microbiol. 2001; 50: 238-242.
- Ubol S, Sukwattanapan C, Utaisincharoen P. Rabies virus replication induced Bax-related, caspase dependent apoptosis in mouse neuroblastoma cell. Virus Research. 1998; 56: 207-215.
Chareeporn Akekawatchai, Marina Kochetkova, Jane Holland and Shaun R. McColl. Chemokine receptor signal transduction in metastatic and nonmetastatic cancer cells. In: Chemokine Receptors and Cancer. A. Fulton (Ed) Human press, a part of Springer science, 2009.
Akekawatchai C. A putative role of CXCR4/CXCR7/CXCL12 chemokine axis in breast cancer cell response to high-dose ascorbic acid treatment: a preliminary study. Joint symposium of Universiti Kebangsaan Malaysia and Thammasat University, 27-28 May, 2015, Faculty of Health Sciences, University Kebangsaan, Malaysia. (Oral presentation)
Akekawatchai C. Changsri K, Soymanee T, Fungkrajay M and Tantipopipat S. High-dose vitamin C modulates CXCR4/CXCR7/CXCL12 chemokine receptor/ligand axis in MDA-MB-231 breast cancer cells. The 17th International Congress of Immunology, Melbourne convention and exhibition centre, Melbourne, Australia, August 21-26, 2016. (Poster presentation)
Chiraunyanann T, Changsri K, Sretapanya W, Yuenyongchaiwat K and Akekawatchai C. Association of the G801A polymorphism in chemokine cxc ligand 12 (CXCL12) gene with liver complication in HIV–infected Thais. The 17th International Congress of Immunology, Melbourne convention and exhibition centre, Melbourne, Australia, August 21-26, 2016. (Oral presentation)
Akekawatchai C, Roytrakul S, Kittisenachai S, Isarankura-Na-Ayudhya P, Koatsawakovit K and Jitrapakdee S. Roles of CXCR4/CXCL12 chemokine receptor/ligand axis in anoikis resistance of breast cancer cells. Asian Leadership for Health Science and Precision Medicine. Institute of Biomedical Industry, The Catholic University of Korea, College of Medicine, Seoul, Korea. June, 2-4, 2017 (Oral presentation)