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ผู้ช่วยศาสตราจารย์ ดร.

จรีภรณ์ เอกวัฒน์ชัย

สาขาวิชาที่เชี่ยวชาญ: ภูมิคุ้มกันวิทยา
หน่วยงาน: ภาควิชาเทคนิคการแพทย์
เบอร์โทรศัพท์: 7147
อีเมล์: cakekawatchai@gmail.com

โครงการวิจัย (Current Project)

List of research projects

2009-2011       Molecular mechanisms involved in the cross-talk between chemokine GPCR and growth factor RTK signal transduction in metastatic breast cancer epithelial cells, Thailand Research Fund (TRF) and Commission on Higher Education (CHE) (Principle investigator)

2009-2011       Anti-cancer mechanisms of vitamin C in different solid tumours, The Thammasat University Research Grant (Principle investigator)

2011-2014       Characterization and detection of cytokines in immunological diseases, The National Research University Project of Thailand, Office of Higher Education Commission (Coinvestigator)

2013-2014      Prevalence and effect of hepatitis virus infection on the severity of HIV infection and hepatotoxicity in HIV-infected Thai individuals receiving anti-retroviral therapy, The fiscal year budget 2013-2014 of Thammasat University (Principle investigator)

2014     Effect of SDF-13’A polymorphism on HIV and hepatitis virus infection in Thais, The Research Grant for Graduate Studies from the National Research Council of Thailand and from Thammasat University (Fiscal year 2014) (Research project advisor)

2015     Mechanisms of CXCR4/CXCR7/CXCL12 signaling in breast cancer cells in response to high-dose vitamin C, Faculty of Allied Health Sciences Research Grant, Thammasat University  (Principle investigator)

2016     Prevalence and risk factors of chronic liver disease, and relationship of CXCL9-11 plasma levels to the severity of liver disease in Thai HIV-infected patients on anti-retroviral therapy, The Fiscal Year Budget 2016 of Thammasat University (Principle investigator)

2018     Effect of interferon gamma inducible protein 10 gene polymorphisms on liver disease in HIV-infected Thais, supported by the Research Grant for Graduate Studies from the National Research Council of Thailand (Fiscal year 2018) (Research project advisor)

2018     Prevalence of liver complications evaluated by non-invasive markers in HCV/HIV coinfected patients in Bamrasnaradura Infectious Diseases Institute, supported by the Research Grant for Graduate Studies from the National Research Council of Thailand (Fiscal year 2018) (Research project advisor)

2019    Study on immunogenetic risk factors for chronic liver disease in HIV-infected Thais, supported by the Fiscal Year Budget 2019 of Thammasat University (Principle investigator)

2019    Antibacterial activity of skin pathogens and cytotoxicity of Ecliptaprostrata Linn. and Dioscoreabulbifera Linn. extract and their chemical composition analyses by iquid chromatography tandem-mass spectrometry (LC MS/MS), supported by the Fiscal Year Budget 2019 of Maejo University (Coinvestigator)

งานวิจัยที่สนใจ (Research Interests)

Research area of interest

  • Immunobiology of cancer metastasis and invasion
  • Molecular virology: virus-host interaction, immunology of hepatitis and human immunodeficiency virus infection

ความเชี่ยวชาญเฉพาะด้าน (Specializations)

Education Qualification

B.Sc. (Medical Technology), Faculty of Medical Technology, Chiang Mai University, Thailand

M.Sc. (Microbiology), Department of Microbiology, Faculty of Sciences, Mahidol University, Thailand

Ph.D. (Molecular Biosciences), Discipline of Microbiology and Immunology, the School of Molecular and Biomedical Science, the University of Adelaide, South Australia, Australia

Scientific Training

2007     Basic Immunology Course for Clinicians at Windsor Barra Hotel, Rio de janerio, Brazil, supported by Cancer Council and School of Molecular and Biomedical Science, The University of Adelaide, South Australia (August 20, 2007)

2011     Analysis of global signal transduction in cancer cells by antibody microarray, Chemokine biology laboratory, School of Molecular and Biomedical Science, The University of Adelaide, South Australia, supported by Chemokine biology laboratory, School of Molecular and Biomedical Science, The University of Adelaide, South Australia and Faculty of Allied Health Sciences, Thammasat University. (March 16-May 1, 2011)

2014     The Second Abbas’s Advanced Course in Basic and Clinical Immunology, Sayamindra building, Siriraj hospital, organized by The Allergy, Asthma and Immunology Association of Thailand (AAIAT) (November 6-8, 2014)

2016     Clinical immunology course associated with The 17th International Congress of Immunology, Melbourne convention and exhibition centre, Australia, supported by Thammasat University. (August 21, 2016)

2017     Genome Evolution of Important Infectious Diseases, at Century park hotel, Bangkok, organized by Department of Microbiology, Faculty of Sciences, Mahidol University. (December 13-15, 2017)

2017     Asian Institute in Statistical Genetics and Genomics (1st South Asian Workshop) at Thammasat University, Rangsit Campus organized by Catholic University of Korea (December 18-19, 2017)

ผลงานอื่น

บทความ

*corresponding author

  1. Apikhun Tunkor, Khaimook Changsri, Thitiilat Chiraunyanan, Warisara Sretapanya and Chareeporn Akekawatchai*. Association of CXCL10 G-201A/C-1596T polymorphisms with Hepatitis B and C infection in human immunodeficiency virus-infected Thais. J Med Tech Assoc Thailand 2018 Dec; 46 (3):6692-6706.
  2. Thitilat Chiraunyanan, Khaimook Changsri, Warisara Sretapanya, Kornanong Yuenyongchaiwat and Chareeporn Akekawatchai*. CXCL12 G801A polymorphism is associated with significant liver fibrosis in HIVinfected Thais: a cross-sectional study. Asian Pac J Allergy Immunol. 2018 Oct 15. doi: 10.12932/AP-160917-0162.
  3. Nalin Wongkattiya, Chareeporn Akekawatchai, Panchana Sanuansermsri, Ian Hamilton Fraser, Chayanin Pratoomsoot and Donruedee Sanguansermsri. Cheminal compositions and biological properties of essential oils from Zanthoxylum Rhetasa (Roxb.) DC and Zanthoxylum Limoella Alston. Afr J Tradit Complement Altern Med 2018 15 (2): 12-18.
  4. Warisara Sretapanya, Thitiilat Chiraunyanan, Duangnate Pipatsatitpong, Thippawan Chuenchitra and Chareeporn Akekawatchai*. Prevalence of hepatotoxicity and factors associated with transaminitis in HIV-infected Thais without hepatitis B and C coinfection. J Med Tech Assoc Thailand 2017 Dec; 45(3):6140-6156.
  5. Akekawatchai C*, Roytrakul S, Kittisenachai S, Isarankura-Na-Ayudhya S and Jitrapakdee S. Protein profiles associated with anoikis resistance of the metastatic MDA-MB-231 breast cancer cells. Asian Pac J Cancer Prev. 2016 March;17(2):581-90.
  6. Akekawatchai C*, Sretapanya W, Pipatsatitpong D and Chuenchit T. Hepatitis B and C virus coinfection and risks for the transaminitis in HIV-infected Thais on combined anti-retroviral therapy. Asian Biomedicine 2015 June 9; 3: 353-361
  7. Meizhi N, Klingler-Hoffmann M, Brazzatti J, Forbes B, Akekawatchai C, Hoffmann P, McColl SR. Comparative proteomic analysis implicates eEF2 as a novel target of PI3Kγ in the MDA-MB-231 metastatic breast cancer cell line. Proteome Sci. 2013 Jan 15; 11(1): 4: 5956-11-4.
  8. Holland JD, Kochetkova M, Akekawatchai C, Dottore M, Lopez A and McColl SR. Differential functional activation of chemokine receptor CXCR4 is mediated by G-proteins in breast cancer cells. Cancer Res. 2006 Apr 15; 66(8):4117-24.
  9. Akekawatchai C, Holland JD, Kochetkova M, Wallace JC and McColl SR. Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells. J Biol Chem. 2005 Dec 2; 280(48): 39701-8.
  10. Ubol S, Sukwattanapan C, Maneerat Y. Inducible nitric oxide synthase inhibition delays death of rabies virus–infected mice. J Med Microbiol. 2001; 50: 238-242.
  11. Ubol S, Sukwattanapan C, Utaisincharoen P. Rabies virus replication induced Bax-related, caspase dependent apoptosis in mouse neuroblastoma cell. Virus Research. 1998; 56: 207-215.

หนังสือ

Book chapter

Chareeporn Akekawatchai, Marina Kochetkova, Jane Holland and Shaun R. McCollChemokine receptor signal transduction in metastatic and nonmetastatic cancer cells. In: Chemokine Receptors and Cancer. A. Fulton (Ed) Human press, a part of Springer science, 2009.

การนำเสนอผลงานทางวิชาการ

Akekawatchai C. A putative role of CXCR4/CXCR7/CXCL12 chemokine axis in breast cancer cell response to high-dose ascorbic acid treatment: a preliminary study. Joint symposium of Universiti Kebangsaan Malaysia and Thammasat University, 27-28 May, 2015, Faculty of Health Sciences, University Kebangsaan, Malaysia. (Oral presentation)

Akekawatchai C. Changsri K, Soymanee T, Fungkrajay M and Tantipopipat S. High-dose vitamin C modulates CXCR4/CXCR7/CXCL12 chemokine receptor/ligand axis in MDA-MB-231 breast cancer cells. The 17th International Congress of Immunology, Melbourne convention and exhibition centre, Melbourne, Australia, August 21-26, 2016. (Poster presentation)

Chiraunyanann T, Changsri K, Sretapanya W, Yuenyongchaiwat K and Akekawatchai C. Association of the G801A polymorphism in chemokine cxc ligand 12 (CXCL12) gene with liver complication in HIVinfected Thais. The 17th International Congress of Immunology, Melbourne convention and exhibition centre, Melbourne, Australia, August 21-26, 2016. (Oral presentation)

Akekawatchai C, Roytrakul S, Kittisenachai S, Isarankura-Na-Ayudhya P, Koatsawakovit K and Jitrapakdee S. Roles of CXCR4/CXCL12 chemokine receptor/ligand axis in anoikis resistance of breast cancer cells. Asian Leadership for Health Science and Precision Medicine. Institute of Biomedical Industry, The Catholic University of Korea, College of Medicine, Seoul, Korea. June, 2-4, 2017 (Oral presentation)

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